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A Phase 2 Study to Evaluate Povetacicept in Adults With Generalized Myasthenia Gravis

RECRUITINGPhase 2Sponsored by Vertex Pharmaceuticals Incorporated
Actively Recruiting
PhasePhase 2
SponsorVertex Pharmaceuticals Incorporated
Started2026-05
Est. completion2029-03-02
Eligibility
Age18 Years – 80 Years
Healthy vol.Accepted
Locations9 sites
View on ClinicalTrials.gov →

NCT07501702

Summary

The purpose of this study is to evaluate the pharmacodynamic (PD) effect, safety, and tolerability of Povetacicept in participants with generalized myasthenia gravis (gMG).

Eligibility

Age: 18 Years – 80 YearsHealthy volunteers accepted
Key Inclusion Criteria:

* Age 18-80 years
* Diagnosis of generalized myasthenia gravis with generalized muscle weakness and fitting MGFA clinical classification II-IV
* Additional inclusion criteria are defined in the protocol

Key Exclusion Criteria:

* History of thymic surgery within 6 months of screening
* History of malignancy within the last 5 years
* Additional exclusion criteria are defined in the protocol

Other protocol defined Inclusion/Exclusion criteria will apply.

Conditions2

CancerMyasthenia Gravis, Generalized

Interventions1

Povetacicept

Locations9 sites

Neurology Offices
Boca Raton, Florida, 33428
SFM Clinical Reseach, LLC
Boca Raton, Florida, 33487
Homestead Associates in Research
Homestead, Florida, 33033
Quantix Research
Miami, Florida, 33173
Hawaii Pacific Neuroscience
Honolulu, Hawaii, 96817

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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