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CHEST: A Collaboration With Community HEalth Centers to Implement SmarT for Asthma

RECRUITINGPhase 4Sponsored by Washington University School of Medicine
Actively Recruiting
PhasePhase 4
SponsorWashington University School of Medicine
Started2026-01-06
Est. completion2027-11-15
Eligibility
Age12 Years+
Healthy vol.Accepted
Locations7 sites

Summary

Purpose: This study aims to improve asthma care by helping clinicians at community health centers prescribe a guideline-recommended treatment called SMART (Single Maintenance and Reliever Therapy). The investigators will provide training and resources to clinicians, give feedback on prescribing patterns, and offer educational tools for patients and providers. The investigators will roll out these resources in stages across clinics. The study will measure how well the program helps clinicians prescribe SMART therapy and whether it reduces asthma exacerbations in patients.

Eligibility

Age: 12 Years+Healthy volunteers accepted
The study population can be viewed from the cluster (clinic), clinician, staff, or patient level.

At the cluster (clinic) level: To be eligible to participate in this study, a cluster (clinic) must meet all the following criteria:

(1) Clinics within participating health systems (Affinia Healthcare and Family Care Health Centers) will be considered eligible if they provided care to ≥100 patients aged ≥12 years with asthma (ICD-10-CM: J45.xx) during the calendar year preceding implementation (2024).

At the clinician level:

Clinicians will be considered eligible if they:

1. are physicians, nurse practitioners, or physician assistants;
2. are actively employed at a participating clinic during the implementation period; and
3. provided care to ≥10 patients aged ≥12 years with asthma (ICD-10-CM: J45.xx) during the 12 months preceding implementation.

At the staff level:

Staff will be considered eligible if they:

1. are actively employed at a participating clinic during the implementation period; and
2. directly support clinical care delivery for patients aged ≥12 years with asthma.

At the patient level:

Patients will be considered eligible if they:

1. are aged ≥12 years;
2. received care at a participating clinic during the implementation period; and (3) meet the study-defined definition of moderate-to-severe asthma based on diagnosis codes, medication use, and/or exacerbation history as defined in the study protocol.

Conditions2

AsthmaModerate to Severe Asthma

Locations7 sites

Affinia healthcare, 2220 Lemp Ave
St Louis, Missouri, 63104
Mellisa Tepe, MD3143769452mtepe@affiniahealthcare.org
Affinia healthcare, 1717 Biddle Street
St Louis, Missouri, 63106
Patrick Schoenwalder, PA-C, MPH314-814-8700pschoenwalder@affiniahealthcare.org
Affinia healthcare, 4414 North Florissant Avenue
St Louis, Missouri, 63107
Catherine Moore, DO309-532-6707camoore@affiniahealthcare.org
Family Care Heath Center, 4352 Manchester Ave
St Louis, Missouri, 63110
Jaime Zengotita, MD3143769452jzengotita@fchcstl.org
Washington University in St. Louis School of Medicine
St Louis, Missouri, 63110
James G Krings, MD314-273-4734kringsj@wustl.edu

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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