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The Perioperative Outcome of Epinephrine Infusion and Tranexamic Acid in Knee Arthroplasty Surgery

RECRUITINGPhase 4Sponsored by King Abdullah International Medical Research Center
Actively Recruiting
PhasePhase 4
SponsorKing Abdullah International Medical Research Center
Started2025-07-15
Est. completion2027-06-24
Eligibility
Age18 Years – 70 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT07089251

Summary

The aim of this clinical trial is to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative blood loss, thromboembolic complications, and hospitalization duration in patients undergoing knee joint arthroplasty. Also aim to evaluate the effect of administering low-dose epinephrine and tranexamic acid on perioperative thromboembolic complications, and hospitalization duration

Eligibility

Age: 18 Years – 70 YearsHealthy volunteers accepted
Inclusion Criteria:

* Patients undergoing knee joint arthroplasty.
* Saudi and Non-Saudi Patient.
* Patients who have Complete medical record.

Exclusion Criteria:

* End stage renal disease
* Liver cirrhosis
* Coagulopathy
* Pre-operative Hgb \<10 5.
* History of cerebrovascular accident or myocardial infarction in past 12 months.
* History of Heart failure.
* History of arrhythmia.
* History of pheochromocytoma, thyrotoxicosis and glaucoma.
* Pregnancy or breast feeding
* History of Deep venous thrombosis or pulmonary embolism
* Allergy to epinephrine or tranexamic acid

Conditions7

ArthritisBlood LossEpinephrineKnee Arthritis, OsteoarthritisKnee Arthroplasty, TotalTotal Knee AnthroplastyTranexamic Acid Use

Interventions2

Tranexamic Acid (TXA) treatmentlow-dose epinephrine and tranexamic acid

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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