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Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

RECRUITINGPhase 1Sponsored by Deciphera Pharmaceuticals, LLC
Actively Recruiting
PhasePhase 1
SponsorDeciphera Pharmaceuticals, LLC
Started2025-08-27
Est. completion2029-02
Eligibility
Age18 Years+
Healthy vol.Accepted
Locations8 sites
View on ClinicalTrials.gov →

NCT06966024

Summary

This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.

Eligibility

Age: 18 Years+Healthy volunteers accepted
Key Inclusion Criteria:

* Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer
* Able to take oral medication
* If a female is of childbearing potential, must have a negative pregnancy test prior to enrollment and all participants agree to follow the contraception requirements
* Adequate organ function and electrolytes

Key Exclusion Criteria:

* Received any prior anticancer therapy or any investigational therapy within a specified timeframe prior to first dose of DCC-2812
* Impaired cardiac function
* Major surgery within 28 days of the first dose of study drug

Conditions4

CancerCastration-resistant Prostate CancerRenal Cell CarcinomaUrothelial Carcinoma

Interventions1

DCC-2812

Locations8 sites

Dana-Farber Cancer Institute
Boston, Massachusetts, 02215
Bicky Thapa, MD617-632-3000bicky_thapa@dfci.harvard.edu
University of Michigan
Ann Arbor, Michigan, 48109
800-865-1125CancerAnswerLine@med.umich.edu
Washington University School of Medicine
St Louis, Missouri, 63110
Hannah Black314-362-9913hannahblack@wustl.edu
Cleveland Clinic
Cleveland, Ohio, 44195
216-444-8311GUPTAS5@ccf.org
Fox Chase Cancer Center
Philadelphia, Pennsylvania, 19111
Courtney Lambert, CRN215-214-3787Courtney.lambert@fccc.edu

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