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Effect of L-Carnitine on Biomarkers of Myocardial Reperfusion Injury in Patients With STEMI

RECRUITINGPhase 2Sponsored by Ain Shams University
Actively Recruiting
PhasePhase 2
SponsorAin Shams University
Started2025-06-01
Est. completion2026-02
Eligibility
Age18 Years – 75 Years
Healthy vol.Accepted
View on ClinicalTrials.gov →

NCT06564909

Summary

The study aims is to evaluate the efficacy and tolerability of L-Carnitine on biomarkers of myocardial reperfusion injury in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary PCI by the assessment of nitrotyrosine as an oxidative stress marker and Matrix metallopeptidase-2 (MMP-2) as a cardiac fibrosis marker

Eligibility

Age: 18 Years – 75 YearsHealthy volunteers accepted
Inclusion Criteria:

* Female or male aged \>18 and \< 75 years.
* STEMI patients undergoing PCI.

Exclusion Criteria:

* Patients with a recent history of myocardial infarction (MI), a previous PCI, a previous coronary artery bypass graft, or any cardiac surgery.
* A late presentation (\>12 h), unsuccessful primary PCI (residual stenosis \>50% in the culprit lesion after procedure),
* Pretreatment with thrombolytic or glycoprotein IIb/IIIa inhibitor therapy before primary PCI,
* Concurrent Infectious or active inflammatory disease,
* Severe liver or renal disease, (aspartate aminotransferase (AST) or alanine transaminase (ALT) \> 3x ULN or Total bilirubin \> 3 x ULN), (CrCl \< 60 ml/min (based on the Cockroft-Gault equation)
* Neoplasm, or hematological disorders
* Pregnant or breast-feeding patients
* Active participation in another clinical study
* Patients taking antioxidant drugs.
* History of or known allergy or intolerability to the study medications

Conditions3

Heart DiseaseMyocardial InfarctionReperfusion Injury, Myocardial

Interventions1

L-Carnitine

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Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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