Heart Disease Clinical Trials in North Carolina

140 recruiting studies across 2 cities

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All Trials in North Carolina

Phase

Trial	Phase	Sponsor	Dist.
Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart Failure	Phase 4	AstraZeneca	<1 mi
A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failure With Rituximab or Rituximab and Chemotherapy	Phase 3	Pierre Fabre Medicament	<1 mi
Combined Dose-Finding and CV Outcomes Study With CSL300 (Clazakizumab) in Adult Subjects With ESKD Undergoing Dialysis (POSIBIL6ESKD)	Phase 2/3	CSL Behring	<1 mi
A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists	Phase 3	Colorado Prevention Center	<1 mi
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure	N/A	Abbott Medical Devices	<1 mi
Fontan Udenafil Exercise Longitudinal Assessment Trial - 2	Phase 3	Mezzion Pharma Co. Ltd	<1 mi
EASi-KIDNEY™ (The Studies of Heart & Kidney Protection With BI 690517 in Combination With Empagliflozin)	Phase 3	Boehringer Ingelheim	<1 mi
CARE-CP (Testing a Cardiovascular Ambulatory Rapid Evaluation for Patients With Chest Pain)	N/A	Wake Forest University Health Sciences	<1 mi
A Study of Vosoritide in Children With Noonan Syndrome With Inadequate Growth During or After Human Growth Hormone Treatment	Phase 2	BioMarin Pharmaceutical	<1 mi
Impact of Bromocriptine on Clinical Outcomes for Peripartum Cardiomyopathy	Phase 4	Dennis M. McNamara, MD, MS	<1 mi
A Trial to Evaluate the Efficacy and Safety of Ninerafaxstat in Patients With Symptomatic Non-obstructive Hypertrophic Cardiomyopathy	Phase 2	Imbria Pharmaceuticals, Inc.	<1 mi
EFS of the CardioMech MVRS	N/A	CardioMech AS	<1 mi
DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting	—	Alnylam Pharmaceuticals	<1 mi
CAPACITY (Cardiac Amyloidosis and Physical ACtivITY) Study	N/A	Wake Forest University Health Sciences	<1 mi
TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy	Phase 3	Alnylam Pharmaceuticals	<1 mi
PARTNER 3 Trial - Aortic Valve-in-Valve	N/A	Edwards Lifesciences	<1 mi
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function	Phase 3	AstraZeneca	<1 mi
AGENT DCB STANCE: Safety and Effectiveness Study of AGENT Drug-Coated Balloon Compared to Standard of Care Percutaneous Coronary Intervention (PCI) Treatment for de Novo Coronary Lesions	N/A	Boston Scientific Corporation	<1 mi
Study to evaLuate the effIcacy and Safety of abeLacimab in High-risk Patients With Atrial Fibrillation Who Have Been Deemed Unsuitable for Oral antiCoagulation (LILAC-TIMI 76)	Phase 3	Anthos Therapeutics, Inc.	<1 mi
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study	N/A	W.L.Gore & Associates	<1 mi
Efficacy of the COronary SInus Reducer in Patients With Refractory Angina II	N/A	Shockwave Medical, Inc.	<1 mi
Anticoagulation in ICH Survivors for Stroke Prevention and Recovery	Phase 3	Yale University	<1 mi
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure	N/A	Procyrion	<1 mi
A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)	—	Bristol-Myers Squibb	<1 mi
A Study of Modified Release RTN-001 In Patients With Uncontrolled Hypertension	Phase 2	Retension Pharmaceuticals. Inc.	<1 mi
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement	N/A	University of British Columbia	<1 mi
Reducing Risk for Infective Endocarditis	N/A	Wake Forest University Health Sciences	<1 mi
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)	Phase 3	Colorado Prevention Center	<1 mi
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure	N/A	Boston Scientific Corporation	<1 mi
ALLIANCE AVIV: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves	N/A	Edwards Lifesciences	<1 mi
Inclisiran Versus Placebo for the Prevention of Major Adverse Cardiovascular and Limb Events in Patients Undergoing Percutaneous Coronary Intervention or Peripheral Endovascular Intervention	Phase 4	Duke University	<1 mi
Left vs Left Randomized Clinical Trial	N/A	Baylor College of Medicine	<1 mi
Abbott Cephea Mitral Valve Disease Registry	—	Abbott Medical Devices	<1 mi
J-Valve Transfemoral Pivotal Study	N/A	JC Medical, Inc., an affiliate of Edwards Lifesciences LLC	<1 mi
ATLAS (AltaValve) Pivotal Trial	N/A	4C Medical Technologies, Inc.	<1 mi
National Collaborative to Improve Care of Children With Complex Congenital Heart Disease	—	Children's Hospital Medical Center, Cincinnati	<1 mi
Assessment of CCM in HF With Higher Ejection Fraction	N/A	Impulse Dynamics	<1 mi
The ENCIRCLE Trial	N/A	Edwards Lifesciences	<1 mi
Cephea Early Feasibility Study	N/A	Abbott Medical Devices	<1 mi
The Multicenter Stress Cardiac Magnetic Resonance Quantitative Perfusion Imaging in the United States Study	N/A	Brigham and Women's Hospital	<1 mi
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin	Phase 3	AstraZeneca	<1 mi
Secondary Mitral Regurgitation Treatment With MitraClip and Assessment by Cardiac Magnetic Resonance	—	Minneapolis Heart Institute Foundation	<1 mi
An Open Label Extension (OLE) Study (Following Completion of CTQJ230A12301) to Evaluate Long-term Safety and Tolerability of Pelacarsen (TQJ230)	Phase 3	Novartis Pharmaceuticals	<1 mi
ALLIANCE: Safety and Effectiveness of the SAPIEN X4 Transcatheter Heart Valve	N/A	Edwards Lifesciences	<1 mi
ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)	—	Emory University	<1 mi
Parasternal Extravascular ICD System Pivotal Clinical Investigation (ALARION EV) Study	N/A	AtaCor Medical, Inc.	<1 mi
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity	Phase 3	Novo Nordisk A/S	<1 mi
A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart	Phase 3	Boehringer Ingelheim	<1 mi
A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure	Phase 3	Boehringer Ingelheim	<1 mi
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products	—	Medtronic	<1 mi
HF2 Registry - Hemodynamic Frontiers in Heart Failure Registry	—	University of Kansas Medical Center	<1 mi
Product Surveillance Registry	—	Medtronic	<1 mi
SELUTION 4 De Novo Small Vessel IDE Trial	N/A	M.A. Med Alliance S.A.	<1 mi
Anticoagulation for New-Onset Post-Operative Atrial Fibrillation After CABG	Phase 3	Icahn School of Medicine at Mount Sinai	<1 mi
Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk	Phase 3	Population Health Research Institute	<1 mi
MagicTouch for Treatment of In-Stent Restenosis in Coronary Artery Lesions	N/A	Concept Medical Inc.	<1 mi
FORWARD CAD IDE Study	N/A	Shockwave Medical, Inc.	<1 mi
MagicTouch™Sirolimus-Coated Balloon for Treatment of Coronary Artery Lesions in Small Vessels	N/A	Concept Medical Inc.	<1 mi
A Study of VARIPULSE Pulsed Field Ablation (PFA) Catheter and FARAWAVE PFA Catheter in the Treatment of Participants With Persistent Atrial Fibrillation	N/A	Biosense Webster, Inc.	<1 mi
Alleviant ALLAY-HF Study	N/A	Alleviant Medical, Inc.	<1 mi
Alleviant ALLAY-HFrEF Study	N/A	Alleviant Medical, Inc.	<1 mi
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction	Phase 3	Cytokinetics	8 mi
A Phase 2 Study of CRD-4730 in CPVT	Phase 2	Cardurion Pharmaceuticals, Inc.	11 mi
Personalized Environment and Genes Study	—	National Institute of Environmental Health Sciences (NIEHS)	15 mi
AMBITION 7: A Research Study Investigating How Well Zenagamtide Lowers Blood Sugar and Body Weight Compared to Insulin Glargine in People With Type 2 Diabetes and Increased Risk of Diseases That Affect the Heart and Blood Vessels Treated With 1-3 Other Diabetes Medications	Phase 3	Novo Nordisk A/S	16 mi
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation for Whom Oral Anticoagulation is Unsuitable	Phase 3	Regeneron Pharmaceuticals	19 mi
Stroke and Systemic Embolism Prevention in Adult Participants With Atrial Fibrillation	Phase 3	Regeneron Pharmaceuticals	19 mi
Ataciguat for Slowing the Progression of Moderate Calcific Aortic Valve Stenosis: A Randomized, Placebo Controlled Study	Phase 2/3	Kardigan, Inc.	21 mi
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events	Phase 3	Amgen	21 mi
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity	Phase 3	Amgen	21 mi
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF	Phase 3	AstraZeneca	21 mi
A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events	N/A	Cleerly, Inc.	21 mi
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes	Phase 4	VA Office of Research and Development	21 mi
Supporting Health in Veterans With Heart Failure	N/A	Florida State University	21 mi
Acoramidis Transthyretin Amyloidosis Prevention Trial in the Young (ACT-EARLY) Study in Asymptomatic Carriers of a Pathogenic TTR Variant	Phase 3	Eidos Therapeutics, a BridgeBio company	21 mi
Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)	—	Duke University	21 mi
The Choice of Vasopressor to Prevent Postoperative Acute Kidney Injury After Major Non-Cardiac Surgery	Phase 4	University of California, San Francisco	21 mi
Multicenter Trial of ECMO in Children With Severe Cardiac Failure Using the Cardiohelp System	Phase 2	Stanford University	21 mi
Medtronic Cardiac Surgery PMCF Registry	—	Medtronic Cardiac Surgery	21 mi
Phase 3 Study on the Efficacy and Safety of Human Plasma Derived Antithrombin (Atenativ) in Heparin-Resistant Patients Scheduled to Undergo Cardiac Surgery Necessitating Cardiopulmonary Bypass	Phase 3	Octapharma	21 mi
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women	Phase 3	Weill Medical College of Cornell University	21 mi
A Study of Mavorixafor in Participants With Congenital and Acquired Primary Autoimmune and Idiopathic Chronic Neutropenic Disorders Who Are Experiencing Recurrent and/or Serious Infections	Phase 3	X4 Pharmaceuticals	21 mi
Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment	N/A	XSpline S.p.A.	21 mi
Modulation of SERCA2a of Intra-myocytic Calcium Trafficking in Heart Failure With Preserved Ejection Fraction	Phase 1	Sardocor Corp.	21 mi
Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients	Phase 2	Baylor Research Institute	21 mi
The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial	Phase 4	VA Office of Research and Development	21 mi
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2	Phase 3	Tenax Therapeutics, Inc.	21 mi
Investigational Trial to Evaluate XC001 Delivered Via an Cardiac Catheter in Subjects With Chronic Angina.	Phase 2	XyloCor Therapeutics, Inc.	21 mi
CORCYM Mitral, Aortic aNd Tricuspid Post-maRket Study in a reAl-world Setting	—	Corcym S.r.l	21 mi
Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery	Phase 1	Pacira Pharmaceuticals, Inc	21 mi
PULSED AF Post-Approval Study	—	Medtronic Cardiac Ablation Solutions	21 mi
Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation.	N/A	Medtronic Cardiovascular	21 mi
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities	Phase 3	Weill Medical College of Cornell University	21 mi
Rare Glycogen Storage Diseases Natural History Study	—	Duke University	21 mi
Comparison of the Outcomes of Single vs Multiple Arterial Grafts in Women	N/A	Weill Medical College of Cornell University	21 mi
Opportunistic PK/PD Trial in Critically Ill Children (OPTIC)	—	Duke University	21 mi
Ventripoint Single Ventricle Study	N/A	Duke University	21 mi
A Phase 1, Dose Escalation Trial of RP-A601 in Subjects With PKP2 Variant-Mediated Arrhythmogenic Cardiomyopathy (PKP2-ACM)	Phase 1	Rocket Pharmaceuticals Inc.	21 mi
Splanchnic X: Splanchnic Nerve Block in Heart Failure With Reduced Ejection Fraction	N/A	Duke University	21 mi
ELEVATE-HFpEF Clinical Study	N/A	Medtronic Cardiac Rhythm and Heart Failure	21 mi
Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study	—	Abbott Medical Devices	21 mi
BiVACOR® Total Artificial Heart Early Feasibility Study	N/A	BiVACOR Inc.	21 mi
PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III	N/A	Endotronix, Inc.	21 mi
A Study to Investigate the Efficacy, Safety, Tolerability and Pharmacokinetics of PKN605 in Participants With Atrial Fibrillation	Phase 2	Novartis Pharmaceuticals	21 mi
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers	N/A	Duke University	21 mi
Sex Differences in Barriers and Participation in Physical Activity During and Following Cardiac Rehabilitation	—	Duke University	21 mi
LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions	Phase 4	Yale University	21 mi
Cord Clamping Among Neonates With Congenital Heart Disease	N/A	Carl Backes, MD	21 mi
XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)	N/A	XVIVO Perfusion	21 mi
COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction	N/A	Edwards Lifesciences	21 mi
PKP2-ACM Natural History Study	—	Rocket Pharmaceuticals Inc.	21 mi
Delayed-Enhancement Cardiovascular Magnetic Resonance in Patients With Sarcoidosis	—	Duke University	21 mi
CTSN Embolic Protection Trial	N/A	Icahn School of Medicine at Mount Sinai	21 mi
A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy	Phase 2	Novo Nordisk A/S	21 mi
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure	N/A	BrioHealth Solutions, Inc.	21 mi
MAGNITUDE: A Phase 3 Study of NTLA-2001 in Participants With Transthyretin Amyloidosis With Cardiomyopathy (ATTR-CM)	Phase 3	Intellia Therapeutics	21 mi
Modeling Mortality in Duchenne Muscular Dystrophy Cardiomyopathy: Identification of Surrogate Outcome Measures for DMD Drug Trials	—	Vanderbilt University Medical Center	21 mi
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis	Phase 3	Duke University	21 mi
A Study to Test How Well BAY 3670549 Works and How Safe it is in Patients With Atrial Fibrillation	Phase 2	Bayer	21 mi
Autus Valve Continued Access Study (CAS)	N/A	Edwards Lifesciences	21 mi
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS	Phase 3	DalCor Pharmaceuticals	23 mi
Real-world Experience of Catheter Ablation for the Treatment of Arrhythmias	—	Heart Rhythm Clinical and Research Solutions, LLC	23 mi
Physical Activity and Community EmPOWERment Project	N/A	University of North Carolina, Chapel Hill	25 mi
Abatacept in Immune Checkpoint Inhibitor Myocarditis	Phase 3	Massachusetts General Hospital	25 mi
Healthy Living Anson Study	N/A	University of North Carolina, Chapel Hill	25 mi
Depression, Aging, Stress and Heart Health Study	N/A	University of North Carolina, Chapel Hill	25 mi
Groundbreaking Renal Assist Device Intervening to ENhance cardioThoracic Surgery Outcomes	N/A	3ive Labs	25 mi
Quality of Pediatric Resuscitation in a Multicenter Collaborative	—	Children's Hospital of Philadelphia	25 mi
The Rhythm Evaluation for AntiCoagulaTion With Continuous Monitoring of Atrial Fibrillation	Phase 3	Johns Hopkins University	25 mi
The EFfect of FinErenone in Kidney TransplantiOn Recipients: The EFFEKTOR Study	Phase 2	University of North Carolina, Chapel Hill	25 mi
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)	N/A	University of Michigan	25 mi
Optimal Ventilation for Cardiac Arrest	N/A	Children's Hospital of Philadelphia	25 mi
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease	—	University of North Carolina, Chapel Hill	25 mi
Inspiring New Science In Guiding Healthcare in Turner Syndrome Registry	—	University of Colorado, Denver	25 mi
Edwards PASCAL Transcatheter Valve Repair System Pivotal Clinical Trial	N/A	Edwards Lifesciences	25 mi
A Study to Evaluate the Efficacy, Safety, Pharmacodynamics (PD), and Pharmacokinetics (PK) of Selnoflast in Reducing Vascular Inflammation in Participants With Atherosclerosis at Risk for Major Adverse Cardiac Events	Phase 2	Genentech, Inc.	25 mi
Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease	Phase 2	UNC Lineberger Comprehensive Cancer Center	25 mi
A Study of LY3971297 in Participants With Heart Failure	Phase 1	Eli Lilly and Company	25 mi
A Usability Study of a Multi-channel ECG Monitoring Device	N/A	Wearlinq	38 mi
S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity	Phase 3	SWOG Cancer Research Network	45 mi

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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