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Tirzepatide Clinical Trials

27 actively recruiting trials across 14 locations

Also known as: GIP/GLP-1RA, LY3298176, LY3298176 (development code name), Mounjaro, Mounjaro (brand name in certain regions) +6 more

Pipeline

Early 1: 2Phase 1: 3Phase 2: 7Phase 3: 4Phase 4: 8Phase 1/2: 1

Top Sponsors

Eli Lilly and Company4
The University of Texas Health Science Center at San Antonio2
University of Miami1
University of Melbourne1
University of Hawaii1

Indications

Diabetes12
Weight Loss9
Obesity8
Cancer7
Heart Disease4

Other12 trials

A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)

Phase 4

A Study to Evaluate the Effect of Fasting Duration and Tirzepatide Withholding on the Amount of Food and Fluid in the Stomach in Participants With Type 2 Diabetes Mellitus and Participants With Overweight or Obesity Without Type 2 Diabetes Mellitus

Phase 1

A Trial Within Cohort Feasibility Study Design Comparing Standard of Care Versus Weight Loss (Achieved Through Tirzepatide) for Obesity-related Hypertension in Young Adults

N/A

Clinical, Morphometric and Biochemical Effects on Adiposopathy Associated With the Use of GLP-1RA in CKD

Effects of Tirzepatide and Insulin Glargine on Glucolipid Metabolism and Brain Function in Patients With Type 2 Diabetes

Phase 4

Efficacy and Safety of Tirzepatide Once Weekly Versus Placebo in Participants Who Are Either Obese or Overweight With Weight-Related Comorbidities (SURMOUNT-1)

Phase 3

GIP/GLP-1RA as Adjunctive to Automated Insulin Delivery in Adults With Type 1 Diabetes

Phase 3

Phase 1/1b Study of TLC-6740 in Healthy Subjects and Subjects With Obesity, With or Without Diabetes

Phase 1

Study of ARO-INHBE in Adults With Obesity With and Without Diabetes Mellitus

Phase 1/2

Subcutaneous Tirzepatide Once-weekly in Patients With Obesity and Knee Osteoarthritis (STOP KNEE-OA)

Phase 4

The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease

Phase 4

Tirzepatide (Spartina) in Obese Kidney Transplant Recipients

Phase 4

San Antonio, Texas2 trials

Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes

University Health System Texas Diabetic Institute

Phase 3

Effects of Tirzepatide on Muscle and Vascular Health in Obese Older Adults

University of Texas Health Science Center at San Antonio

Phase 2

Tuscaloosa, Alabama1 trial

A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)

MFA Clinical Research

Phase 3

Avondale, Arizona1 trial

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale

Phase 4

Duarte, California1 trial

Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

City of Hope Medical Center

Phase 2

Tarzana, California1 trial

Evaluation of Tirzepatide as an Adjunct to Buprenorphine for the Treatment of Opioid Use Disorder

Tarzana Treatment Centers

Phase 2

Torrance, California1 trial

Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT

Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center (The Lundquist Institute)

Phase 4

Miami, Florida1 trial

Glucagon-like Peptide-1 Receptor Agonist (GLP-1 RA) and Diet in Inflammatory Bowel Disease (IBD) Patients

University of Miami

Phase 4

Honolulu, Hawaii1 trial

Effects of Tirzepatide on Weight Loss and Chronic Inflammation in People With HIV

John A Burns School of Medicine

Phase 2

Boston, Massachusetts1 trial

Pathways, Risk Factors, and mOleculeS to Prevent Early-onset Colorectal Tumors

Massachusetts General Hospital Cancer Center

Phase 1

Basking Ridge, New Jersey1 trial

A Study of a Weight Loss Intervention in People With Endometrial Cancer

Memorial Sloan Kettering Basking Ridge

Early 1

Elizabeth, New Jersey1 trial

Tirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer

Trinitas Comprehensive Cancer Center

Phase 2

Cleveland, Ohio1 trial

TIRzepatide for the Treatment of Obesity in Patients With Atrial Fibrillation

Cleveland Clinic

Phase 2

Dallas, Texas1 trial

Tirzepatide Weight Loss for MRD+ Early Breast Cancer

Baylor University Medical Center, Baylor Charles A Sammons Cancer Center

Phase 2

Houston, Texas1 trial

Pre-Surgical Tirzepatide-Assisted Weight Loss in Overweight and Obese Men With Intermediate Risk Prostate Cancer: A Pilot Feasibility Study

The University of Texas M. D. Anderson Cancer Center

Early 1

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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