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Metformin Clinical Trials

59 actively recruiting trials across 16 locations

Also known as: Fortamet, Glucient, Glucophage, Glucophage extended release (XR), Glucophage, Glucophage XR, Fortamet, and Glumetza +10 more

Pipeline

Early 1: 2Phase 1: 5Phase 2: 22Phase 3: 9Phase 4: 11Phase 1/2: 4Phase 2/3: 1

Top Sponsors

University of California, San Francisco3
Mostafa Bahaa3
The University of Texas Health Science Center at San Antonio2
Karolinska Institutet2
Assistance Publique - Hôpitaux de Paris2

Indications

Cancer24
Diabetes22
Metformin5
Heart Disease4
Arthritis4

Other39 trials

A Clinical Trial to Evaluate the Efficacy, Tolerability, and Safety of a Fixed Dose Combination of Spironolactone, Pioglitazone & Metformin (SPIOMET) in Polycystic Ovary Syndrome (PCOS)

Phase 2

A Phase I Double Blind Study of Metformin Acting on Endogenous Neural Progenitor Cells in Children and Young Adults With Multiple Sclerosis

Phase 1/2

A Phase IV Clinical Trial to Compare the Efficacy and Safety of Metformin+Sodium-Glucose Cotransporter 2 Inhibitor(SGLT2-i)+Thiazolidinedione (TZD) in Patients With Type 2 Diabetes

Phase 4

Acupuncture or Metformin for Insulin Resistance in Women With PCOS

Phase 2

Acute Portal Pressure Reduction by Metformin and Carvedilol Compared to Carvedilol Alone in Cirrhosis.

N/A

Anti-atherosclerotic Efficacy of Selected Antidiabetic Drugs in Patients With Coronary Artery Disease and Pre-diabetes

Phase 4

CRD vs. Met in Patients With Obese PCOS Infertility

N/A

Chemoradiotherapy With or Without Metformin in Locally Advanced Cervical Cancer

Phase 2

Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease

Phase 2

Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostat on Gouty Obese Non-Diabetic Patients

Phase 2

Durable Effect of Imeglimin on the Glycemic Control in Patients With Type 2 Diabetes Mellitus

Phase 4

Effect of Metformin Use on Weight Loss in Obese, Non-diabetic People (MOWRI)

Phase 3

Effect of Tofogliflozin on UACR Compared to Metformin Hydrochloride in Diabetic Kidney Disease (TRUTH-DKD)

Phase 2

Effects of Metformin on Hepatic Venous Pressure Gradient in Patients With Cirrhosis and Portal Hypertension

Phase 2

Efficacy and Safety of Add-On Therapy With Empagliflozin in Patients With Type 2 Diabetes on a Background of Alogliptin and Metformin

Phase 3

Efficacy and Safety of Henagliflozin Proline and Metformin Hydrochloride Extended-release Tablets (Ⅰ) Versus Metformin Tablets in Patients With New-onset Type 2 Diabetes: a Multicenter, Randomized Controlled Study

Phase 4

Efficacy and Safety of Madalena Association in the Treatment of Type II Diabetes Mellitus

Phase 3

Efficacy and Safety of the Met+SGLT-2i+GLP-1RA in Patients With Type 2 Diabetes With Poor Glycemic Control

Phase 4

Efficacy of Dapagliflozin Versus Metformin in Polycystic Ovary Syndrome

Phase 3

Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care

Phase 3

Fish Oil, Metformin and Heart Health in PCOS

Phase 1

Glycemic Variability of Combination Therapies in T2DM

Phase 4

Gut-Brain-axis: Targets for Improvement of Cognition in the Elderly

Impact of P53 and SIRT1 in Type 2 Diabetes

Phase 3

Liraglutide Treatment in Obese Infertile PCOS Women

Phase 4

Metformin Safety and Efficacy in Osteoarthritis.

Phase 3

Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET)

Phase 3

Metformin as a Metabolic Intervention in Oesophageal Adenocarcinomas to Improve Response to Neoadjuvant Chemoradiotherapy

Phase 2

Metformin in Post Chronic Pancreatitis Diabetes Mellitus

Phase 4

Metformin in Safety and Efficacy in Gouty Patients

Phase 2

Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide

Phase 2

PCOS Immune Function Predicts Metformin Efficacy

N/A

Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma

Phase 2

Phase II Study of Oral Metformin for Intravesical Treatment of Non-muscle-invasive Bladder Cancer

Phase 2

Relapse in Previously Irradiated Prostate Bed : Stereotactic Ablative Reirradiation Potentiated by Metformin

Phase 1/2

Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

Phase 2

SGLT2 Inhibitors As First Line Therapy to Prevent Renal Decline in Type 2 Diabetes

Phase 3

Safety and Efficacy of Venetoclax, Cytarabine and Metformin (VenCM) for Relapsed-Refractory and Induction-Ineligible Acute Myeloid Leukemia

Phase 2

The EMPA-FIT Study

Phase 4

San Francisco, California2 trials

Metformin for Pulmonary Hypertension HFpEF

UCSF Medical Center

Phase 2

Target Validation and Efficacy of Metformin in Patients With Posterior Fossa Group A (PFA) Ependymoma

University of California, San Francisco

Phase 2

Chicago, Illinois2 trials

Effect of Continuing Versus Holding Metformin During Hospitalizations.

University of Illinois at Chicago

Phase 4

Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-Cessation

AgelessRx

Phase 2/3

Pittsburgh, Pennsylvania2 trials

A Trial of Pembrolizumab and Metformin Versus Pembrolizumab Alone in Advanced Melanoma

Univ of Pittsburgh Medical Center Hillman Cancer Center

Phase 1

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

UPMC Hillman Cancer Center

Phase 2

San Antonio, Texas2 trials

Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

The University of Texas Health Science Center at San Antonio

N/A

Prevention of Progression of Prediabetes, Obesity and CV Risk

University of Texas Health Science Center at San Antonio

Phase 1

Tuscaloosa, Alabama1 trial

DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

University of Alabama

Phase 4

Little Rock, Arkansas1 trial

A Feasibility Study Evaluating a Role for Maintenance Therapy in Patients With Biochemically Progressive Castration Sensitive Prostate Cancer on Intermittent Androgen Deprivation Therapy

University of Arkansas for Medical Sciences

Phase 1

Duarte, California1 trial

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

City of Hope

Phase 1/2

Oakland, California1 trial

Precision Dosing of Metformin in Youth With T2D

UCSF Benioff Children's Hospital Oakland, Pediatric Diabetes Clinic

Early 1

Aurora, Colorado1 trial

Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients

Colorado Research Center

Early 1

Atlanta, Georgia1 trial

Preventing Injured Knees From osteoArthritis: Severity Outcomes

Emory University

Phase 2

Indianapolis, Indiana1 trial

The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action

Indiana University School of Medicine

Phase 2

Louisville, Kentucky1 trial

A Phase I/II Trial of Vemurafenib and Metformin to Melanoma Patients

James Graham Brown Cancer Center-University of Louisville

Phase 1/2

Boston, Massachusetts1 trial

RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer

Massachusetts General Hospital Cancer Center

Phase 2

Detroit, Michigan1 trial

Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies

Karmanos Cancer Institute

Phase 1

Rochester, Minnesota1 trial

Remote Cognitive Assessment and Wearable Device While Assessing the Impact of Metformin in Patients With History of Cranial Radiation Therapy

Mayo Clinic in Rochester

Phase 2

Buffalo, New York1 trial

Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)

UBMD Neurolgy

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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