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Giredestrant Clinical Trials

7 actively recruiting trials across 4 locations

▼ -1 trial since August 2026

Also known as: GDC-9545, RG6171, RO7197597

Pipeline

Phase 2: 2Phase 3: 1Phase 1/2: 4

Top Sponsors

  • Hoffmann-La Roche3
  • Genentech, Inc.2
  • MedSIR1
  • Alliance Foundation Trials, LLC.1

Indications

  • Cancer7
  • Breast Cancer6
  • Inoperable, Locally Advanced or Metastatic, ER-positive Breast Cancer1
  • Metastatic Breast Cancer1
  • Early Breast Cancer1

Duarte, California3 trials

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

City of Hope

Phase 1/2
A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

City of Hope - Duarte

Phase 1/2
A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

City of Hope Comprehensive Cancer Center

Phase 1/2

Other1 trial

A PoC Study to Evaluate Treatments' Efficacy by Monitoring MRD Using ctDNA in HR-positive/HER2-negative EBC Population
Phase 2

Tucson, Arizona1 trial

A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer

University of Arizona Cancer Center

Phase 1/2

Fountain Valley, California1 trial

A Study Evaluating Adherence, Tolerability, and Patient Reported Outcomes of Giredestrant in Participants With ER+/HER2- Early Breast Cancer Who Are Intolerant to Adjuvant Aromatase Inhibitor Therapy (novERA Breast Cancer)

Orange Coast Medical Center

Phase 3

Los Angeles, California1 trial

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Los Angeles Cancer Network

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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