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Datopotamab Deruxtecan Clinical Trials

9 actively recruiting trials across 6 locations

Also known as: DS-1062, DS-1062; DS-1062a, Dato-DXd, DS-1062a, Dato-DXd, Datopotamab Deruxtecan: Dato-DXd, DS-1062a +1 more

Pipeline

Phase 2: 6Phase 3: 3

Top Sponsors

  • AstraZeneca2
  • UNC Lineberger Comprehensive Cancer Center1
  • Sarah Sammons, MD1
  • QuantumLeap Healthcare Collaborative1
  • Medical University of Vienna1

Indications

  • Cancer9
  • Breast Cancer5
  • Lung Cancer4
  • HER2-negative Breast Cancer3
  • Non Small Cell Lung Cancer3

Other2 trials

A Single Arm, Phase 2 Study of Datopotamab Deruxtecan, Carboplatin, and Pembrolizumab for Treatment-naive Brain Metastases From NSCLC (Non-small Cell Lung Cancer)
Phase 2
Phase II Study of Dato-DXd in Triple-negative Breast Cancer Patients With Newly Diagnosed or Progressing Brain Metastases
Phase 2

Birmingham, Alabama2 trials

I-SPY TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer

University of Alabama at Birmingham

Phase 2
TReatment of ADC-Refractory Breast CancEr With Dato-DXd or T-DXd: TRADE DXd

University of Alabama

Phase 2

Anchorage, Alaska1 trial

Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

Research Site

Phase 3

Chandler, Arizona1 trial

Study of Dato-DXd Plus Pembrolizumab vs Pembrolizumab Alone in the First-line Treatment of Subjects With Advanced or Metastatic NSCLC Without Actionable Genomic Alterations

Ironwood Cancer and Research Center

Phase 3

Fountain Valley, California1 trial

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

Research Site

Phase 3

Miami, Florida1 trial

DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

Miami Baptist Cancer Institute/

Phase 2

Chapel Hill, North Carolina1 trial

PREDICT-RD: ctDNA Surveillance in TNBC With Residual Disease

UNC Lineberger Comprehensive Cancer Center

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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