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Dalpiciclib Clinical Trials

13 actively recruiting trials

No change since August 2026

Also known as: CDK4/6 inhibitor, SHR-6390, SHR6390

Pipeline

Phase 1: 1Phase 2: 9Phase 3: 1

Top Sponsors

  • Hebei Medical University Fourth Hospital3
  • Fudan University3
  • Tongji Hospital1
  • The First Affiliated Hospital with Nanjing Medical University1
  • Sun Yat-sen University1

Indications

  • Cancer13
  • Breast Cancer12
  • Hormone Receptor Positive Tumor2
  • HER2-negative Breast Cancer2
  • Advanced Breast Cancer2

Other13 trials

A Randomised, Open-label, Multicentre Phase III Clinical Study to Evaluate the Efficacy and Safety of JS105 Combined With Dalpiciclib and Fulvestrant Compared With Dalpiciclib and Fulvestrant in Patients With PIK3CA-mutated, HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer.
Phase 3
Adebrelimab Combined With Dalpiciclib and Standard Endocrine Therapy for HR+/HER2 - Advanced Breast Cancer
Phase 2
Dalpiciclib Plus AI (Neoadjuvant Endocrine Therapy) Compared With Neoadjuvant Chemotherapy in Early Breast Cancer （EBC）
Phase 2
Dalpiciclib With or Without Entinostat and Letrozole in HR+/HER2- Early Breast Cancer
Phase 2
Dalpiciclib in HR+/HER2- ABC
Dalpiciclib, Anti-HER2 Therapy, and Endocrine Therapy for Hormone-Receptor-Positive, HER2-Positive Metastatic Breast Cancer
Phase 2
Efficacy and Safety of Dalpiciclib With Endocrine Therapy as Adjuvant Treatment in HR+/ HER2- Early Breast Cancer
Phase 2
Efficacy and Safety of Dalpiciclib in Hormone Receptor-positive Advanced Breast Cancer
Fudan University Shanghai Cancer Center Breast Cancer Precision Platform Series Study- Neoadjuvant Therapy
Phase 2
IN10018 in Combination With Dalpiciclib for Progressive Meningiomas
Phase 1
PARP Inhibitor With CDK4/6 Inhibitor and Endocrine Therapy in HR+/ HER2-Advanced Breast Cancer
Phase 2
Pyrotinib Combined With Trastuzumab, Dalpiciclib, Letrozole Versus TCbHP (Trastuzumab Plus Pertuzumab With Docetaxel and Carboplatin) as Neoadjuvant Treatment in HR +/HER2 + Breast Cancer
Phase 2
SNF Platform Study of HR+/ HER2-advanced Breast Cancer
Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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