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Botensilimab Clinical Trials

14 actively recruiting trials across 8 locations

Also known as: AGEN 1181, AGEN-1181, AGEN1181, Anti-CTLA-4 Monoclonal Antibody AGEN1181, BOT

Pipeline

Phase 1: 2Phase 2: 9Phase 3: 2Phase 2/3: 1

Top Sponsors

  • Memorial Sloan Kettering Cancer Center3
  • Weill Medical College of Cornell University1
  • University of Southern California1
  • University of Colorado, Denver1
  • The Netherlands Cancer Institute1

Indications

  • Cancer14
  • Colorectal Cancer5
  • Liver Disease1
  • Microsatellite Stable Rectal Carcinoma1
  • Glioblastoma, Isocitric Dehydrogenase (IDH)-Wildtype1

Other4 trials

Botensilimab + Balstilimab vs Best Supportive Care as Therapy in Chemo-refractory, Unresectable, Colorectal Adenocarcinoma
Phase 3
Combination of Immune Checkpoint in Locally Advanced or Metastatic MSI/dMMR Esogastric Adenocarcinomas
Phase 3
Pan-tumor Neoadjuvant Basket Study of Immune Check-point Inhibition and Novel Immuno-oncology Combinations
Phase 2/3
Pre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)
Phase 2

Basking Ridge, New Jersey3 trials

A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 2
A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 2
A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)

Phase 2

Duarte, California1 trial

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

City of Hope Medical Center

Phase 2

Fullerton, California1 trial

Botensilimab Plus Balstilimab and Fasting Mimicking Diet Plus Vitamin C for Patients With KRAS-Mutant Metastatic Colorectal Cancer

Saint Jude Medical Center / Providence Medical Foundation

Phase 1

Aurora, Colorado1 trial

Doxorubicin Plus Dual Checkpoint Blockade for Soft Tissue Sarcomas

University of Colorado Hospital

Phase 2

Miami, Florida1 trial

The Miami "EMPIRE" Trial - Eradication of Metastatic Pancreatic Cancer With Immuno-Radiation

University of Miami

Phase 2

Chicago, Illinois1 trial

Phase 2a Immune Modulation With Ultrasound for Newly Diagnosed Glioblastoma

Northwestern University

Phase 2

Baltimore, Maryland1 trial

KRAS-Targeted Vaccine Combined With Balstilimab and Botensilimab for Patients With Stage IV MMR-p Colorectal Cancer and Pancreatic Ductal Cancer

Sidney Kimmel Comprehensive Cancer Center

Phase 1

New York, New York1 trial

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

Weill Cornell Medicine/NewYork-Presbyterian Hospital

Phase 2

Trial data from ClinicalTrials.gov. Trial status and eligibility can change — verify directly with the study contact or on ClinicalTrials.gov.

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